Pack Article Directory Curaçao: 2011

Saturday 24 December 2011

Lorcamin

Lorcamin may be available in the countries listed below.

Ingredient matches for Lorcamin

Norfloxacin

Norfloxacin is reported as an ingredient of Lorcamin in the following countries:

Greece

International Drug Name Search

Monday 19 December 2011

Démanol (acéglutamate de)

Démanol (acéglutamate de) may be available in the countries listed below.

Ingredient matches for Démanol (acéglutamate de)

Deanol

Démanol (acéglutamate de) (DCF) is also known as Deanol (BAN)

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française

Click for further information on drug naming conventions and International Nonproprietary Names.

Sunday 11 December 2011

Mansil

Mansil may be available in the countries listed below.

Ingredient matches for Mansil

Oxamniquine

Oxamniquine is reported as an ingredient of Mansil in the following countries:

Brazil

International Drug Name Search

Sunday 4 December 2011

Belladonna

Class: Antimuscarinics/Antispasmodics
VA Class: AU350
CAS Number: 8007-93-0
Brands: Antispasmodic, B & O Supprettes, Donnatal, Hyonatol

Introduction

Antimuscarinic; naturally occurring mixture of tertiary amine alkaloids.^a ^c

Uses for Belladonna

Peptic Ulcer Disease

Adjunct in the treatment of peptic ulcer disease; however, no conclusive data that it aids in the healing, decreases the rate of recurrence, or prevents complications of peptic ulcers.^a ^b ^h ⁱ With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition.^a

Has been used in combination with other drugs (e.g., phenobarbital);^a ^b ^h ⁱ however, no data support superiority of combination preparations over antimuscarinics alone.^a

GI Motility Disorders

Treatment of functional disturbances of GI motility (e.g., irritable bowel syndrome) and neurogenic bowel disturbances;^a however, efficacy is limited.^a Use only if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit.^a

Has been used in combination with other drugs (e.g., phenobarbital) in the treatment of functional disturbances of GI motility such as irritable bowel syndrome;^a ^b ^h ⁱ however, such combined therapy lacks substantial evidence of efficacy.^a

Use with extreme caution, if at all, in the treatment of hypermotility and diarrhea associated with GI disorders such as acute enterocolitis.^a

Pain

Has been used rectally in combination with opium in patients unresponsive to nonopiate analgesics for symptomatic relief of moderate to severe pain following GU surgery and for relief of pain caused by ureteral spasm. ^a ^g

Parkinsonian Syndrome

Treatment of mild cases of parkinsonian syndrome or as an adjunct to other therapy; however, antimuscarinics generally have been replaced with dopaminergic drugs.^a

Belladonna Dosage and Administration

Administration

Administer orally or rectally.^a ^b ^g ^h ⁱ

Oral Administration

Administer orally as belladonna tincture or extract or as conventional or extended-release tablets or oral solution (elixir) containing belladonna alkaloids in fixed combination with other drugs (e.g., phenobarbital).^a ^b ^h ⁱ

Belladonna extract powder used extemporaneously to prepare capsules, powders, or tablets for oral administration. ^a

Belladonna leaf itself is not used as a therapeutic agent because of risk of overdosage of the alkaloids.^a

Some clinicians have preferred belladonna tincture to other antimuscarinics because it usually is the most economic and easily titrated antimuscarinic.^a

Rectal Administration

Moisten rectal suppositories containing belladonna and opium with water prior to rectal insertion.^a ^g

Dosage

Carefully titrate dosage until therapeutic effect is achieved or adverse effects become intolerable.^a Higher than recommended dosage may be required for therapeutic effect.^a Use lowest possible effective dosage.^a

Pediatric Patients

General Dosage

Oral

Belladonna tincture: Usual initial dosage is 0.1 mL (0.03 mg of the alkaloids of belladonna leaf) per kg daily or 2.5 mL (0.75 mg of the alkaloids of belladonna leaf) per m² daily, given in 3 or 4 divided doses; do not exceed 3.5 mL (1.05 mg of the alkaloids of belladonna leaf) daily.^a

Peptic Ulcer Disease and GI Motility Disorders

Oral

Belladonna alkaloids and phenobarbital (e.g., Donnatal elixir): Administer every 4–6 hours based on weight and symptoms.^h (See Table 1.)

Table 1. Initial Pediatric Dosage of Belladonna Alkaloids and Phenobarbital (e.g., Donnatal elixir)h
Body Weight	Dose Every 4 Hours	Dose Every 6 Hours
4.5 kg	0.5 mL	0.75 mL
9.1 kg	1 mL	1.5 mL
13.6 kg	1.5 mL	2 mL
22.7 kg	2.5 mL	3.75 mL
34 kg	3.75 mL	5 mL
45.4 kg	5 mL	7.5 mL

Pain

Pain Following GU Surgery or Caused by Ureteral Spasm

Rectal

Adolescents ≥13 years of age: 16.2 mg of belladonna extract (0.203 mg of the alkaloids of belladonna leaf) in fixed combination with 30 or 60 mg of opium (1 suppository) once or twice daily.^a ^g

Adults

General Dosage

Oral

Belladonna extract: Usual initial dosage is 15–30 mg (0.187–0.374 mg of the alkaloids of belladonna leaf) 3 or 4 times daily.^a

Belladonna tincture: Usual initial dosage is 0.6–1 mL (0.18–0.3 mg of the alkaloids of belladonna leaf) 3 or 4 times daily.^a

Peptic Ulcer Disease and GI Motility Disorders

Oral

Belladonna extract: Usual initial dosage is 15–30 mg (0.187–0.374 mg of the alkaloids of belladonna leaf) 3 or 4 times daily.^a

Belladonna tincture: Usual initial dosage is 0.6–1 mL (0.18–0.3 mg of the alkaloids of belladonna leaf) 3 or 4 times daily.^a

Immediate-release tablets or solution (elixir) containing belladonna alkaloids and phenobarbital (e.g., Donnatal): 1 or 2 tablets or 5 or 10 mL of elixir 3 or 4 times daily.^h ⁱ

Extended-release tablets containing belladonna alkaloids and phenobarbital (Donnatal Extentabs): Usual dosage is 1 tablet every 12 hours; may administer 1 tablet every 8 hours if indicated.^b

Pain

Pain Following GU Surgery or Caused by Ureteral Spasm

Rectal

16.2 mg of belladonna extract (0.203 mg of the alkaloids of belladonna leaf) in fixed combination with 30 or 60 mg of opium (1 suppository) once or twice daily.^a ^g

Prescribing Limits

Pediatric Patients

Belladonna tincture: Maximum 3.5 mL (1.05 mg of the alkaloids of belladonna leaf) daily.^a

Adults

Suppositories containing belladonna extract in fixed combination with 30 or 60 mg of opium: Maximum 64.8 mg of belladonna extract (0.812 mg of the alkaloids of belladonna leaf; equivalent to 4 suppositories) daily. ^a ^g

Special Populations

Hepatic Impairment

No specific hepatic dosage recommendations for belladonna.^a ^b

When used in fixed combination with phenobarbital, use small initial dosage.^b ^h ⁱ

Avoid use of belladonna and opium suppositories in severe hepatic disease.^g

Renal Impairment

No specific renal dosage recommendations for belladonna.^a ^b

Avoid use of belladonna and opium suppositories in severe renal disease.^g

Geriatric Patients

Adjust dosage based on patient tolerance and response.^c

Cautions for Belladonna

Contraindications

Angle-closure glaucoma.^b ^c ^g ^h ⁱ

Obstructive uropathy (e.g., bladder neck obstruction secondary to prostatic hypertrophy).^b ^c ^h ⁱ

Obstructive GI disease (e.g., pyloroduodenal stenosis, achalasia).^b ^c ^h ⁱ

Paralytic ileus.^b ^c ^h ⁱ

Intestinal atony (especially in geriatric or debilitated patients).^b ^c ^h ⁱ

Acute hemorrhage when cardiovascular status is unstable. ^b ^c ^h ⁱ

Tachycardia secondary to cardiac insufficiency or thyrotoxicosis.^c

Severe ulcerative colitis or toxic megacolon complicating ulcerative colitis.^b ^c ^h ⁱ

Myasthenia gravis^b ^h ⁱ (unless used to reduce adverse muscarinic effects of an anticholinesterase agent such as neostigmine).^c

Some manufacturers state that belladonna is contraindicated in patients with hiatal hernia with reflux esophagitis.^b ^h ⁱ (See GI Effects under Cautions.)

Known hypersensitivity to belladonna or any ingredient in the formulation.^b ^c ^h ⁱ

Warnings/Precautions

Warnings

Thermoregulatory Effects

Exposure to high environmental temperatures may result in heat prostration due to decreased sweating.^b ^c ^h ⁱ Increased risk of hyperthermia in patients who are febrile.^c

Diarrhea

May be an early sign of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy; in this instance, use would be inappropriate and possibly harmful.^b ^c ^h ⁱ

Drowsiness and Blurred Vision

May cause drowsiness, dizziness, or blurred vision.^b ^c ^g ^h ⁱ Performance of activities requiring mental alertness and physical coordination may be impaired.^b ^c ^g ^h ⁱ

Major Toxicities

Overdosage

A curare-like action may occur (e.g., neuromuscular blockade leading to muscular weakness and possible paralysis).^b ^c ^h ⁱ

General Precautions

Use of Fixed Combinations

When belladonna is used in fixed combination with phenobarbital or opium, consider cautions, precautions, and contraindications associated with the concomitant agent(s).^a ^b ^g ^h ⁱ

Concomitant Illnesses

Use with caution in patients with hyperthyroidism, autonomic neuropathy, hepatic or renal disease, CHD, CHF, cardiac arrhythmias, or hypertension.^b ^c ^h ⁱ

GI Effects

Extreme caution in known or suspected GI infections because of decreased GI motility and retention of causative organism and/or toxins.^c

Extreme caution in mild to moderate ulcerative colitis because of suppressed intestinal motility and resultant paralytic ileus and toxic megacolon.^c

Caution in gastric ulcer because of delayed gastric emptying and possible antral stasis.^b ^c

Caution in esophageal reflux and hiatal hernia because of decreased gastric motility and lower esophageal sphincter pressure leading to gastric retention and reflux aggravation.^c Some manufacturers state that belladonna is contraindicated in these patients.^b ^h ⁱ

GU Disturbances

Extreme caution in patients with partial obstructive uropathy because of decreased tone and amplitude of contractions of ureters and bladder and resultant urinary retention.^c (See Contraindications under Cautions.)

Respiratory Effects

Caution with systemically administered antimuscarinics in debilitated patients with chronic pulmonary disease because a reduction in bronchial secretions may lead to inspissation and formation of bronchial plugs.^c

Down’s Syndrome, Spastic Paralysis, and Brain Damage

Increased sensitivity to antimuscarinic effects (e.g., mydriasis, positive chronotropic effect).^c (See Pediatric Use under Cautions.)

Specific Populations

Pregnancy

Category C.^b ^d ^g ^h ⁱ

Lactation

Not known whether belladonna is distributed into milk.^b ^d ^g ^h ⁱ Caution if used in nursing women.^b ^g ^h ⁱ

Pediatric Use

Safety of belladonna established in pediatric patients.^c

Safety and efficacy of belladonna extract not established in children.^a Manufacturer states that belladonna and opium suppositories are not recommended in children ≤12 years of age.^g

Children with spastic paralysis or brain damage may have increased sensitivity to antimuscarinic effects (e.g., mydriasis, positive chronotropic effect).^c

Infants and young children may be especially susceptible to toxic effects of anticholinergics.^c

Geriatric Use

Use with caution.^c ^g

Geriatric patients especially susceptible to antimuscarinic effects (e.g., constipation, dry mouth, urinary retention).^c Mental confusion and/or excitement is especially likely in geriatric patients.^c Excitement, agitation, or drowsiness possible even with small dosages.^b ^h ⁱ

Hepatic Impairment

Use with caution in hepatic disease.^b ^c ^h

Renal Impairment

Use with caution in renal disease.^b ^c ^h

Common Adverse Effects

Drowsiness,^b ^g ^h ⁱ xerostomia,^b ^c ^g ^h ⁱ tachycardia,^b ^c ^g ^h ⁱ palpitation,^b ^c ^h ⁱ dizziness,^b ^g ^h ⁱ nervousness,^b ^h ⁱ urinary hesitancy and retention,^b ^c ^g ^h ⁱ decreased sweating,^b ^c ^h ⁱ constipation,^b ^c ^h ⁱ increased ocular tension,^b ^h ⁱ photophobia,^c ^g blurred vision,^b ^c ^g ^h ⁱ mydriasis.^b ^c ^h ⁱ

Interactions for Belladonna

Drugs with Anticholinergic Effects

Additive adverse effects resulting from cholinergic blockade (e.g., xerostomia, blurred vision, constipation).^c Advise of possibility of increased anticholinergic effects and monitor carefully. ^c

Effects on GI Absorption of Drugs

By inhibiting the motility of the GI tract and prolonging GI transit time, antimuscarinics have the potential to alter GI absorption of various drugs.^c

Specific Drugs

Drug	Interaction	Comments
Amantadine	Additive anticholinergic effects^c	Inform patient of this possibility^c
Antacids	May interfere with belladonna absorption^c	Administer belladonna at least 1 hour before antacids^c
Antiarrhythmic (anticholinergic) agents	Additive anticholinergic effects^c	Inform patient of this possibility^c
Antidepressants, tricyclic	Additive anticholinergic effects^c	Inform patient of this possibility^c
Antihistamines (anticholinergic) (including meclizine)	Additive anticholinergic effects^c	Inform patient of this possibility^c
Antiparkinsonian (antimuscarinic) agents	Additive anticholinergic effects^c	Inform patient of this possibility^c
Corticosteroids	Possible increased IOP^c
Digoxin (slow dissolving)	Possible increased serum digoxin concentration^c	Use digoxin oral solution (elixir) or rapidly dissolving tablets (e.g., Lanoxin)^c Observe closely for signs of digitalis toxicity^c
Glutethimide	Additive anticholinergic effects^c	Inform patient of this possibility^c
Ketoconazole	Increased gastric pH decreases ketoconazole absorption^c	Administer belladonna at least 2 hours after ketoconazole^c
Levodopa	Possible increased GI metabolism of levodopa and decreased systemic concentrations^c	Adjust levodopa dosage if belladonna is started or discontinued^c
Meperidine	Additive anticholinergic effects^c	Inform patient of this possibility^c
Muscle (anticholinergic) relaxants	Additive anticholinergic effects^c	Inform patient of this possibility^c
Phenothiazines	Additive anticholinergic effects^c	Inform patient of this possibility^c
Potassium chloride	Slowed GI transit potentiates adverse GI effects of oral potassium chloride (especially wax-matrix tablets)^c	Caution if used concomitantly; monitor for possible GI mucosal lesions^c

Belladonna Pharmacokinetics

Absorption

Bioavailability

Well absorbed from the GI tract; however, animal studies have shown differences in the absorption rates of l-hyoscyamine and galenical preparations of belladonna.^a

Distribution

Extent

Not known whether belladonna is distributed into milk.^b ^d ^g ^h ⁱ

Atropine, hyoscyamine, and scopolamine cross the placenta.^c

Atropine and hyoscyamine readily cross the blood-brain barrier.^c

Elimination

Metabolism

Hydrolyzed to tropine and tropic acid.^a

Elimination Route

Excreted in urine and, apparently to a lesser extent, in feces.^a

Stability

Storage

Oral

Belladonna Leaf

Tight, light-resistant containers.^a

Belladonna Extract

Tight containers at ≤30°C.^a

Belladonna Tincture

Tight, light-resistant containers at <40°C (maintain between 15–30°C).^a Protect from direct sunlight and excessive heat.^a

Belladonna Alkaloids with Phenobarbital Elixir and Immediate- and Extended-release Tablets

Well-closed, light-resistant containers at 20–25°C.^b ^h ⁱ Protect from light and moisture.^b ^h ⁱ

Rectal

Suppositories

15–30°C.^g Do not refrigerate.^g

ActionsActions

Belladonna is a term applied to the various galenical preparations of the naturally occurring solanaceous alkaloids.^a Antimuscarinic activity results principally from the atropine (dl-hyoscyamine) content.^a ^g

Competitively inhibits acetylcholine or other cholinergic stimuli at autonomic effectors innervated by postganglionic cholinergic nerves and, to a lesser extent, on smooth muscles that lack cholinergic innervation.^c At usual doses, principally antagonizes cholinergic stimuli at muscarinic receptors and has little or no effect on cholinergic stimuli at nicotinic receptors.^c

Antimuscarinics also have been referred to as anticholinergics (cholinergic blocking agents), but this term is appropriate only when it describes the antagonism of cholinergic stimuli at any cholinergic receptor, whether muscarinic or nicotinic.^c

Also have been referred to as parasympatholytics because the antagonized functions principally are under the parasympathetic division of the nervous system.^c

Receptors at various sites are not equally sensitive to inhibition of muscarinic effects.^c Relative sensitivity of physiologic functions (proceeding from the most sensitive) is as follows: secretions of the salivary, bronchial, and sweat glands; pupillary dilation, ocular accommodation, and heart rate; contraction of the detrusor muscle of the bladder and smooth muscle of the GI tract; and gastric secretion and motility.^c Doses used to decrease gastric secretions are likely to cause dryness of the mouth (xerostomia) and interfere with visual accommodation, and possibly cause difficulty in urinating.^c

Various antisecretory effects in the GI tract, including reduction of salivation (producing xerostomia) and gastric secretions (only partial reduction in gastric acid secretion).^c Prolonged inhibitory effects on the motility of the esophagus, stomach, duodenum, jejunum, ileum, and colon.^c

Relaxes lower esophageal sphincter with a resultant decrease in lower esophageal sphincter pressure.^c

Decreases the tone and amplitude of contractions of the ureters and bladder.^c May cause urinary retention (e.g., in patients with urinary obstruction).^c

Can reverse reflex vagal cardiac slowing or asystole such as that induced by inhalation of irritant vapors or by vagal stimulation (e.g., carotid sinus stimulation, pressure on the eyeball).^c

May cause cutaneous vasodilation, especially at toxic doses (atropine flush).^c

Reduces secretions from the nose, mouth, pharynx, and bronchi.^c Relaxes smooth muscles of the bronchi and bronchioles with a resultant decrease in airway resistance.^c

Stimulates the medulla and higher cerebral centers and exhibits CNS effects similar to those produced by antimuscarinics used in the treatment of parkinsonian syndrome (e.g., trihexyphenidyl).^c

Blocks the responses of the sphincter muscle of the iris and the ciliary muscle of the lens to cholinergic stimulation, producing mydriasis and cycloplegia and a resultant decrease in ocular accommodation.^c Little effect on IOP except with angle-closure glaucoma where IOP may increase.^c

Reduces the volume of perspiration by inhibiting sweat-gland secretions.^c May suppress sweating sufficiently to increase body temperature.^c

Advice to Patients

Potential for hyperthermia and heat prostration;^b ^c ^h ⁱ avoid exposure to high environmental temperatures and avoid use when febrile.^c

If rectal suppositories are prescribed, instruct patient or caregiver in the proper administration technique.^a

Risk of drowsiness, dizziness, or blurred vision; use caution when driving or operating machinery until effects on individual are known.^b ^c ^g ^h ⁱ

Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.^b ^c ^g ^h ⁱ

Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.^b ^g ^h ⁱ

Importance of informing patients of other important precautionary information.^b ^c ^g ^h ⁱ (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Belladonna
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Bulk	Leaf*	USP (with at least 0.35% w/w of the alkaloids)
Oral	Tincture*	0.3 mg of the alkaloids of belladonna leaf per mL with alcohol 67%

Belladonna Alkaloids Combinations
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Oral	Solution	Atropine Sulfate 0.0194 mg/5 mL, Hyoscyamine Sulfate 0.1037 mg/5 mL, Phenobarbital 16.2 mg/5 mL, and Scopolamine Hydrobromide 0.0065 mg/5 mL	AntispasmodicElixir (with alcohol 23%)	Morton Grove
			Donnatal Elixir (with alcohol 23%)	PBM
			Phenobarb with Belladonna Alkaloids Elixir	Vintage
	Tablets	Atropine Sulfate 0.0194 mg, Hyoscyamine Sulfate 0.1037 mg, Phenobarbital 16.2 mg, and Scopolamine Hydrobromide 0.0065 mg	Belladonna Alkaloids with Phenobarb Tablets	Vintage, West-Ward
			Donnatal	PBM
			Hyonatol	Western Research
	Tablets, extended-release	Atropine Sulfate 0.0582 mg, Hyoscyamine Sulfate 0.3111 mg, Phenobarbital 48.6 mg, and Scopolamine Hydrobromide 0.0195 mg	Donnatal Extentabs	PBM

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Belladonna Extract
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Bulk	Powder*

Belladonna Extract Combinations
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Rectal	Suppositories	16.2 mg (0.21 mg of the alkaloids of belladonna leaf) with Powdered Opium 30 mg	Belladonna & Opium Suppositories (C-II)	Paddock
			B & O Supprettes No. 15A (C-II)	PolyMedica
		16.2 mg (0.21 mg of the alkaloids of belladonna leaf) with Powdered Opium 60 mg	Belladonna & Opium Suppositories (C-II)	Paddock
			B & O Supprettes No. 16A (C-II)	PolyMedica

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 05/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Belladonna Alk-Phenobarbital 16.2MG Tablets (WEST-WARD): 60/$14.99 or 120/$18.97

Donnatal Tablets (PBM PHARMACEUTICALS): 60/$39.99 or 180/$89.97

Donnatal 16.2MG/5ML Elixir (PBM PHARMACEUTICALS): 118/$33.99 or 354/$97.97

Donnatal Extentabs Controlled-release Tablets (PBM PHARMACEUTICALS): 30/$50.99 or 90/$125.97

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions December 01, 2009. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

a. AHFS drug information 2007. McEvoy GK, ed. Belladonna. Bethesda, MD: American Society of Health-System Pharmacists; 2007:1272-3.

b. PBM Pharmaceuticals. Donnatal Extentabs (phenobarbital, hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide) extended-release tablets prescribing information. Gordonsville, VA; 2004 Jun.

c. AHFS drug information 2007. McEvoy GK, ed. Antimuscarinics/antispasmodics general statement. Bethesda, MD: American Society of Health-System Pharmacists; 2007:1259-67.

d. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation. 7th ed. Baltimore, MD: Williams & Wilkins; 2005:149-50.

f. Food and Drug Administration. FDA takes action to halt marketing of unapproved ergotamine— Companies ordered to cease manufacturing and distribution of illegal drugs to treat migraine headaches. FDA News. March 1, 2007. From FDA website.

g. Amerifit Pharma. B & O Supprettes (belladonna and opium) rectal suppositories prescribing information. Woburn, MA. Undated.

h. PBM Pharmaceuticals. Donnatal Elixir (phenobarbital, hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide) prescribing information. Gordonsville, VA; 2004 Aug.(

i. PBM Pharmaceuticals. Donnatal (phenobarbital, hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide) immediate release tablet prescribing information. Gordonsville, VA; 2004 Nov.(

j. Food and Drug Administration. Ergotamine tartrate. Rockville, MD; 2007 Mar 2. From FDA website.

k. Food and Drug Administration. Warning letters for ergotamine-containing drug products (issued February 26, 2007). From FDA web site.

l. North American Menopause Society. Treatment of menopause-associated vasomotor symptoms: position statement of the North American Menopause Society. Menopause. 2004; 11:11-33. [PubMed 14716179]

More Belladonna resources

Belladonna Side Effects (in more detail)
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Saturday 3 December 2011

Dolofur

Dolofur may be available in the countries listed below.

Ingredient matches for Dolofur

Metamizole

Metamizole sodium monohydrate (a derivative of Metamizole) is reported as an ingredient of Dolofur in the following countries:

Mexico

International Drug Name Search

Bisoprolol dura

Bisoprolol dura may be available in the countries listed below.

Ingredient matches for Bisoprolol dura

Bisoprolol

Bisoprolol fumarate (a derivative of Bisoprolol) is reported as an ingredient of Bisoprolol dura in the following countries:

Germany

International Drug Name Search

Sunday 27 November 2011

Tenoxitic

Tenoxitic may be available in the countries listed below.

Ingredient matches for Tenoxitic

Tenoxicam

Tenoxicam is reported as an ingredient of Tenoxitic in the following countries:

Vietnam

International Drug Name Search

Primesin

Primesin may be available in the countries listed below.

Ingredient matches for Primesin

Fluvastatin

Fluvastatin sodium salt (a derivative of Fluvastatin) is reported as an ingredient of Primesin in the following countries:

Italy

International Drug Name Search

Saturday 26 November 2011

Ambroxol Bexal

Ambroxol Bexal may be available in the countries listed below.

Ingredient matches for Ambroxol Bexal

Ambroxol

Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Ambroxol Bexal in the following countries:

Spain

International Drug Name Search

Friday 25 November 2011

Panadol Extra

Panadol Extra may be available in the countries listed below.

Ingredient matches for Panadol Extra

Caffeine

Caffeine is reported as an ingredient of Panadol Extra in the following countries:

Croatia (Hrvatska)

Ireland

New Zealand

Singapore

Slovakia

Slovenia

Switzerland

Vietnam

Paracetamol

Paracetamol is reported as an ingredient of Panadol Extra in the following countries:

Croatia (Hrvatska)

Hong Kong

Ireland

New Zealand

Singapore

Slovakia

Slovenia

Switzerland

Vietnam

International Drug Name Search

Monday 21 November 2011

Litomerin

Litomerin may be available in the countries listed below.

Ingredient matches for Litomerin

Ritodrine

Ritodrine hydrochloride (a derivative of Ritodrine) is reported as an ingredient of Litomerin in the following countries:

Japan

International Drug Name Search

Sunday 20 November 2011

Dermaclob

Dermaclob may be available in the countries listed below.

Ingredient matches for Dermaclob

Clobetasol

Clobetasol 17α-propionate (a derivative of Clobetasol) is reported as an ingredient of Dermaclob in the following countries:

Argentina

International Drug Name Search

Saturday 19 November 2011

Rinafed

Rinafed may be available in the countries listed below.

Ingredient matches for Rinafed

Pseudoephedrine

Pseudoephedrine hydrochloride (a derivative of Pseudoephedrine) is reported as an ingredient of Rinafed in the following countries:

Vietnam

Triprolidine

Triprolidine hydrochloride monohydrate (a derivative of Triprolidine) is reported as an ingredient of Rinafed in the following countries:

Vietnam

International Drug Name Search

Fenitoina Ges

Fenitoina Ges may be available in the countries listed below.

Ingredient matches for Fenitoina Ges

Phenytoin

Phenytoin sodium salt (a derivative of Phenytoin) is reported as an ingredient of Fenitoina Ges in the following countries:

Spain

International Drug Name Search

Tuesday 15 November 2011

Silycon

Silycon may be available in the countries listed below.

Ingredient matches for Silycon

Silibinin

Silibinin is reported as an ingredient of Silycon in the following countries:

Taiwan

International Drug Name Search

Asmalair

Asmalair may be available in the countries listed below.

Ingredient matches for Asmalair

Montelukast

Montelukast sodium salt (a derivative of Montelukast) is reported as an ingredient of Asmalair in the following countries:

Ecuador

International Drug Name Search

Monday 14 November 2011

Naxy

Naxy may be available in the countries listed below.

Ingredient matches for Naxy

Clarithromycin

Clarithromycin is reported as an ingredient of Naxy in the following countries:

France

International Drug Name Search

Ranir

Ranir may be available in the countries listed below.

Ingredient matches for Ranir

Ranitidine

Ranitidine is reported as an ingredient of Ranir in the following countries:

Myanmar

International Drug Name Search

Sunday 13 November 2011

Ocid

Ocid may be available in the countries listed below.

Ingredient matches for Ocid

Omeprazole

Omeprazole is reported as an ingredient of Ocid in the following countries:

Eritrea

Ethiopia

India

Kenya

Latvia

Lithuania

Myanmar

Nigeria

Russian Federation

Singapore

Sri Lanka

Tanzania

Thailand

Uganda

Vietnam

Zambia

Zimbabwe

International Drug Name Search

Friday 11 November 2011

Karon

Karon may be available in the countries listed below.

Ingredient matches for Karon

Alprostadil

Alprostadil is reported as an ingredient of Karon in the following countries:

Czech Republic

Slovakia

International Drug Name Search

Thursday 10 November 2011

Vitamine A Faure

Vitamine A Faure may be available in the countries listed below.

Ingredient matches for Vitamine A Faure

Retinol

Retinol is reported as an ingredient of Vitamine A Faure in the following countries:

Monaco

Tunisia

International Drug Name Search

Wednesday 9 November 2011

Sadolin

Sadolin may be available in the countries listed below.

Ingredient matches for Sadolin

Somatostatin

Somatostatin x acetate (a derivative of Somatostatin) is reported as an ingredient of Sadolin in the following countries:

Greece

International Drug Name Search

Saturday 5 November 2011

Espasmokolic

Espasmokolic may be available in the countries listed below.

Ingredient matches for Espasmokolic

Clonixin

Clonixin lysine salt (a derivative of Clonixin) is reported as an ingredient of Espasmokolic in the following countries:

Peru

Pargeverine

Pargeverine hydrochloride (a derivative of Pargeverine) is reported as an ingredient of Espasmokolic in the following countries:

Peru

International Drug Name Search

Wednesday 2 November 2011

A-Parkin

A-Parkin may be available in the countries listed below.

Ingredient matches for A-Parkin

Amantadine

Amantadine sulfate (a derivative of Amantadine) is reported as an ingredient of A-Parkin in the following countries:

Israel

International Drug Name Search

Clarute

Clarute may be available in the countries listed below.

Ingredient matches for Clarute

Diltiazem

Diltiazem hydrochloride (a derivative of Diltiazem) is reported as an ingredient of Clarute in the following countries:

Japan

International Drug Name Search

Hyamine

Hyamine may be available in the countries listed below.

Ingredient matches for Hyamine

Benzethonium Chloride

Benzethonium Chloride is reported as an ingredient of Hyamine in the following countries:

Japan

International Drug Name Search

Enalapril Finlay

Enalapril Finlay may be available in the countries listed below.

Ingredient matches for Enalapril Finlay

Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enalapril Finlay in the following countries:

Honduras

International Drug Name Search

Tuesday 25 October 2011

Monosulfiram

Monosulfiram may be available in the countries listed below.

Ingredient matches for Monosulfiram

Sulfiram

Monosulfiram (BAN) is also known as Sulfiram (Rec.INN)

International Drug Name Search

Glossary

BAN	British Approved Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Wednesday 19 October 2011

Losartan-HCT axcount

Losartan-HCT axcount may be available in the countries listed below.

Ingredient matches for Losartan-HCT axcount

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Losartan-HCT axcount in the following countries:

Germany

Losartan

Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Losartan-HCT axcount in the following countries:

Germany

International Drug Name Search

Monday 17 October 2011

Augmentin oral

Augmentin oral may be available in the countries listed below.

Ingredient matches for Augmentin oral

Amoxicillin

Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Augmentin oral in the following countries:

Chile

Vietnam

Clavulanate

Clavulanic Acid potassium (a derivative of Clavulanic Acid) is reported as an ingredient of Augmentin oral in the following countries:

Chile

Vietnam

International Drug Name Search

Saturday 15 October 2011

Beneflux

Beneflux may be available in the countries listed below.

Ingredient matches for Beneflux

Ambroxol

Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Beneflux in the following countries:

Peru

International Drug Name Search

Tuesday 11 October 2011

Adofeed

Adofeed may be available in the countries listed below.

Ingredient matches for Adofeed

Flurbiprofen

Flurbiprofen is reported as an ingredient of Adofeed in the following countries:

Japan

International Drug Name Search

Friday 7 October 2011

Cardem

Cardem may be available in the countries listed below.

Ingredient matches for Cardem

Celiprolol

Celiprolol hydrochloride (a derivative of Celiprolol) is reported as an ingredient of Cardem in the following countries:

Spain

International Drug Name Search

Rhutasuppo

Rhutasuppo may be available in the countries listed below.

Ingredient matches for Rhutasuppo

Ketoprofen

Ketoprofen is reported as an ingredient of Rhutasuppo in the following countries:

Tunisia

International Drug Name Search

Wednesday 5 October 2011

Hyalozima

Hyalozima may be available in the countries listed below.

Ingredient matches for Hyalozima

Hyaluronidase

Hyaluronidase is reported as an ingredient of Hyalozima in the following countries:

Brazil

International Drug Name Search

Tuesday 4 October 2011

Atralin

In the US, Atralin (tretinoin topical) is a member of the drug class topical acne agents and is used to treat Acne and Photoaging of the Skin.

US matches:

Atralin

Atralin Topical

Atralin Gel

Ingredient matches for Atralin

Sertraline

Sertraline is reported as an ingredient of Atralin in the following countries:

Bangladesh

Tretinoin

Tretinoin is reported as an ingredient of Atralin in the following countries:

United States

International Drug Name Search

Saturday 1 October 2011

Hirudoid

Hirudoid may be available in the countries listed below.

UK matches:

Hirudoid Cream (SPC)
Hirudoid Gel (SPC)

Ingredient matches for Hirudoid

Chondroitin Polysulfate

Chondroitin Polysulfate is reported as an ingredient of Hirudoid in the following countries:

Australia

Austria

Bahrain

Belgium

Brazil

Czech Republic

Denmark

Estonia

Germany

Hong Kong

Iceland

India

Italy

Latvia

Lithuania

Luxembourg

Malta

Myanmar

Netherlands

New Zealand

Norway

Peru

Poland

Singapore

Slovakia

Spain

Sweden

Switzerland

Thailand

United Kingdom

Venezuela

Glucosaminoglycan Polysulfate

Glucosaminoglycan Polysulfate is reported as an ingredient of Hirudoid in the following countries:

Vietnam

Sodium Alginate Sulfate

Sodium Alginate Sulfate is reported as an ingredient of Hirudoid in the following countries:

Japan

International Drug Name Search

Glossary

SPC

Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Saturday 24 September 2011

Trisekvens

Trisekvens may be available in the countries listed below.

Ingredient matches for Trisekvens

Estradiol

Estradiol is reported as an ingredient of Trisekvens in the following countries:

Denmark

Estradiol hemihydrate (a derivative of Estradiol) is reported as an ingredient of Trisekvens in the following countries:

Finland

Norway

Sweden

Norethisterone

Norethisterone 17ß-acetate (a derivative of Norethisterone) is reported as an ingredient of Trisekvens in the following countries:

Denmark

Sweden

International Drug Name Search

Wednesday 21 September 2011

Hippomec

Hippomec may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Hippomec

Ivermectin

Ivermectin is reported as an ingredient of Hippomec in the following countries:

Netherlands

International Drug Name Search

Lipilim

Lipilim may be available in the countries listed below.

Ingredient matches for Lipilim

Clofibrate

Clofibrate is reported as an ingredient of Lipilim in the following countries:

Hong Kong

International Drug Name Search

Sunday 18 September 2011

Migrafen

Migrafen may be available in the countries listed below.

Ingredient matches for Migrafen

Pizotifen

Pizotifen is reported as an ingredient of Migrafen in the following countries:

Bangladesh

International Drug Name Search

Sunday 11 September 2011

Cipralex

Cipralex may be available in the countries listed below.

UK matches:

Cipralex 20 mg/ml oral drops, solution
Cipralex 5, 10, 15, and 20 mg Film-Coated Tablets

Ingredient matches for Cipralex

Escitalopram

Escitalopram is reported as an ingredient of Cipralex in the following countries:

Latvia

Slovakia

Spain

Turkey

Escitalopram oxalate (a derivative of Escitalopram) is reported as an ingredient of Cipralex in the following countries:

Austria

Bahrain

Bulgaria

Canada

Croatia (Hrvatska)

Czech Republic

Denmark

Estonia

Finland

Georgia

Germany

Greece

Hungary

Iceland

India

Israel

Italy

Lithuania

Malta

Norway

Oman

Portugal

Russian Federation

Serbia

Slovenia

South Africa

Sweden

Switzerland

United Kingdom

International Drug Name Search

Tuesday 6 September 2011

Riper

Riper may be available in the countries listed below.

Ingredient matches for Riper

Risperidone

Risperidone is reported as an ingredient of Riper in the following countries:

Taiwan

International Drug Name Search

Monday 5 September 2011

Hydracort

Hydracort may be available in the countries listed below.

Ingredient matches for Hydracort

Hydrocortisone

Hydrocortisone is reported as an ingredient of Hydracort in the following countries:

France

International Drug Name Search

Vancomycin Alpharma

Vancomycin Alpharma may be available in the countries listed below.

Ingredient matches for Vancomycin Alpharma

Vancomycin

Vancomycin hydrochloride (a derivative of Vancomycin) is reported as an ingredient of Vancomycin Alpharma in the following countries:

Denmark

Finland

Iceland

Oman

International Drug Name Search

Saturday 3 September 2011

Reset

Reset may be available in the countries listed below.

Ingredient matches for Reset

Paracetamol

Paracetamol is reported as an ingredient of Reset in the following countries:

Bangladesh

International Drug Name Search

Thursday 25 August 2011

Ovurila

Ovurila may be available in the countries listed below.

Ingredient matches for Ovurila

Ketoprofen

Ketoprofen is reported as an ingredient of Ovurila in the following countries:

Indonesia

International Drug Name Search

Wednesday 24 August 2011

Helimox

Helimox may be available in the countries listed below.

Ingredient matches for Helimox

Clarithromycin

Clarithromycin is reported as an ingredient of Helimox in the following countries:

Ecuador

International Drug Name Search

Sunday 21 August 2011

W-Tropfen

W-Tropfen may be available in the countries listed below.

Ingredient matches for W-Tropfen

Lactic Acid

Lactic Acid is reported as an ingredient of W-Tropfen in the following countries:

Germany

Salicylic Acid

Salicylic Acid is reported as an ingredient of W-Tropfen in the following countries:

Germany

International Drug Name Search

Saturday 20 August 2011

Soprerole

Soprerole may be available in the countries listed below.

Ingredient matches for Soprerole

Isosorbide Mononitrate

Isosorbide Mononitrate is reported as an ingredient of Soprerole in the following countries:

Japan

International Drug Name Search

Tuesday 16 August 2011

Alfuzosina Ciclum

Alfuzosina Ciclum may be available in the countries listed below.

Ingredient matches for Alfuzosina Ciclum

Alfuzosin

Alfuzosin is reported as an ingredient of Alfuzosina Ciclum in the following countries:

Portugal

International Drug Name Search

Wednesday 10 August 2011

Antrolin

Antrolin may be available in the countries listed below.

Ingredient matches for Antrolin

Lidocaine

Lidocaine hydrochloride (a derivative of Lidocaine) is reported as an ingredient of Antrolin in the following countries:

Italy

Nifedipine

Nifedipine is reported as an ingredient of Antrolin in the following countries:

Italy

International Drug Name Search

Thursday 4 August 2011

Vincristine Sulfate David Bull

Vincristine Sulfate David Bull may be available in the countries listed below.

Ingredient matches for Vincristine Sulfate David Bull

Vincristine

Vincristine sulfate (a derivative of Vincristine) is reported as an ingredient of Vincristine Sulfate David Bull in the following countries:

Greece

International Drug Name Search

Wednesday 27 July 2011

Tiamvet

Tiamvet may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Tiamvet

Tiamulin

Tiamulin fumarate (a derivative of Tiamulin) is reported as an ingredient of Tiamvet in the following countries:

France

Germany

Italy

International Drug Name Search

Tuesday 26 July 2011

Bicalutamide Qualimed

Bicalutamide Qualimed may be available in the countries listed below.

Ingredient matches for Bicalutamide Qualimed

Bicalutamide

Bicalutamide is reported as an ingredient of Bicalutamide Qualimed in the following countries:

France

International Drug Name Search

Monday 25 July 2011

Vegevit B12

Vegevit B12 may be available in the countries listed below.

Ingredient matches for Vegevit B12

Cyanocobalamin

Cyanocobalamin is reported as an ingredient of Vegevit B12 in the following countries:

Poland

International Drug Name Search

Sunday 24 July 2011

Oxytetracycline Hydrochloride

Ingredient matches for Oxytetracycline Hydrochloride

Oxytetracycline

Oxytetracycline Hydrochloride (BANM, JAN) is known as Oxytetracycline in the US.

International Drug Name Search

Glossary

BANM	British Approved Name (Modified)
JAN	Japanese Accepted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Saturday 23 July 2011

Hemsyl

Hemsyl may be available in the countries listed below.

Ingredient matches for Hemsyl

Etamsylate

Etamsylate is reported as an ingredient of Hemsyl in the following countries:

India

International Drug Name Search

Tuesday 19 July 2011

Histaler

Histaler may be available in the countries listed below.

Ingredient matches for Histaler

Diphenhydramine

Diphenhydramine hydrochloride (a derivative of Diphenhydramine) is reported as an ingredient of Histaler in the following countries:

Argentina

International Drug Name Search

Friday 15 July 2011

Enap HL

Enap HL may be available in the countries listed below.

Ingredient matches for Enap HL

Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enap HL in the following countries:

Singapore

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Enap HL in the following countries:

Singapore

International Drug Name Search

Wednesday 13 July 2011

diazoxide

Generic Name: diazoxide (oral) (DYE az OX ide)

Brand names: Proglycem, Hyperstat

What is diazoxide?

Diazoxide given orally raises blood sugar by slowing the release of insulin from the pancreas.

Diazoxide is used to treat low blood sugar (hypoglycemia) related to certain cancers that affect the pancreas and cause it to release too much insulin.

Diazoxide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about oral diazoxide?

You should not take this medication if you are allergic to diazoxide or diuretics (water pills). Oral diazoxide should not be used to treat occasional hypoglycemia related to diet.

Before taking diazoxide, tell your doctor if you have congestive heart failure, kidney disease, gout, high cholesterol, or low potassium.

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

If your blood sugar gets too high (hyperglycemia), you may have symptoms such as increased thirst, loss of appetite, fruity breath odor, increased urination, drowsiness, dry skin, nausea, and vomiting. Tell your doctor right away if you have any of these symptoms.

To be sure this medication is helping your condition and not causing harmful effects, your urine will need to be tested often for the presence of glucose (sugar) or ketones. You may be able to do this testing at home. Call your doctor if you have any abnormal test result.

Your doctor may also want you to have blood or urine tests at regular intervals. Do not miss any scheduled appointments.

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are taking diazoxide.

If your condition does not improve after taking diazoxide for 2 to 3 weeks, stop taking the medication and talk to your doctor.

What should I discuss with my health care provider before receiving diazoxide?

You should not take this medication if you are allergic to diazoxide or diuretics (water pills). Oral diazoxide should not be used to treat occasional hypoglycemia related to diet.

Before taking diazoxide, tell your doctor if you are allergic to any drugs, or if you have:

congestive heart failure;

kidney disease;

gout;

high cholesterol or triglycerides; or

low levels of potassium in your blood (hypokalemia).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take diazoxide.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant before you take diazoxide. Diazoxide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take diazoxide?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with the marked medicine dropper provided, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Diazoxide usually begins to work within 1 hour, and its effects can last up to 8 hours.

Your doctor may also want you to have blood or urine tests at regular intervals. Do not miss any scheduled appointments. If your condition does not improve after taking diazoxide for 2 to 3 weeks, stop taking the medication and talk to your doctor. Store diazoxide at room temperature away from moisture, heat, and light.

See also: Diazoxide dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include increased thirst or urination, fruity breath odor, nausea, and vomiting, or feeling like you might pass out.

What should I avoid while taking diazoxide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are taking diazoxide.

Diazoxide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

shortness of breath, swelling in your hands or feet;

rapid pulse;

fast or pounding heartbeats;

chest pain;

blurred vision, eye pain, or seeing halos around lights;

easy bruising or bleeding, unusual weakness;

fever, chills, body aches, flu symptoms;

urinating less than usual; or

feeling like you might pass out.

Less serious side effects may include:

temporary increase in growth of body hair (especially in women and children;

nausea, vomiting, stomach pain, loss of appetite;

diarrhea;

decreased sense of taste;

headache, dizziness, anxiety;

weakness; or

mild itching or skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Diazoxide Dosing Information

Usual Adult Dose for Hypertensive Emergency:

IV: 1 to 3 mg/kg up to a maximum of 150 mg every 5 to 15 minutes, then every 4 to 24 hours. It should be administered in less than 30 seconds into a peripheral vein.

Usual Adult Dose for Hypoglycemia:

3 to 8 mg/kg/day orally in divided doses every 8 or 12 hours. Higher dosages (up to 15 mg/kg/day) have been used in refractory hypoglycemia.

Usual Pediatric Dose for Hypertensive Emergency:

1 to 5 mg/kg IV up to a maximum of 150 mg every 5 to 15 minutes, then every 4 to 24 hours. The dose should be administered in less than 30 seconds into a peripheral vein. Alternatively, 3 to 5 mg/kg infused over 30 minutes may result in less hypotension and hyperglycemia.

Usual Pediatric Dose for Hypoglycemia:

Hyperinsulinemic hypoglycemia:
less than 1 month: Initial: 10 mg/kg/day orally in divided doses every 8 hours; usual range: 5 to 15 mg/kg/day orally in divided doses every 8 hours
less than 1 year: Initial: 10 mg/kg/day orally in divided doses every 8 hours; usual range: 5 to 20 mg/kg/day orally in divided doses every 8 hours
1 year or older: Initial: 3 mg/kg/day orally in divided doses every 8 hours; usual range: 3 to 8 mg/kg/day orally in divided doses every 8 to 12 hours

Higher dosages (up to 15 mg/kg/day) have been used in refractory hypoglycemia.

What other drugs will affect diazoxide?

The following drugs can interact with diazoxide. Tell your doctor if you have recently taken any of these:

a diuretic (water pill);

chlorpromazine (Thorazine);

phenytoin (Dilantin);

a blood thinner such as warfarin (Coumadin); or

drugs to treat high blood pressure or a prostate disorder, such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), tamsulosin (Flomax).

This list is not complete and there may be other drugs that can interact with diazoxide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More diazoxide resources

Diazoxide Side Effects (in more detail)
Diazoxide Dosage
Diazoxide Use in Pregnancy & Breastfeeding
Diazoxide Drug Interactions
Diazoxide Support Group
0 Reviews for Diazoxide - Add your own review/rating

diazoxide Advanced Consumer (Micromedex) - Includes Dosage Information

Diazoxide Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

Diazoxide Monograph (AHFS DI)

Hyperstat Prescribing Information (FDA)

Proglycem Prescribing Information (FDA)

Compare diazoxide with other medications

Hypertensive Emergency
Hypoglycemia

Where can I get more information?

Your doctor or pharmacist can provide more information about diazoxide.

See also: diazoxide side effects (in more detail)