Perizin may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Coumafos is reported as an ingredient of Perizin in the following countries:
International Drug Name Search
Definition of Erythromelalgia: Erythromelalgia is a rare neurovascular peripheral nerve disorder in which blood vessels, usually in the lower extremities (or hands), are episodically blocked, then become hyperemic and inflamed. There is severe burning pain and skin redness associated with the return of blood flow following the transient vasospasm. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia and stress.
The following drugs and medications are in some way related to, or used in the treatment of Erythromelalgia. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
Micromedex Care Notes:
Trepidan may be available in the countries listed below.
Prazepam is reported as an ingredient of Trepidan in the following countries:
International Drug Name Search
Pents may be available in the countries listed below.
Domperidone is reported as an ingredient of Pents in the following countries:
Pantoprazole is reported as an ingredient of Pents in the following countries:
International Drug Name Search
Aspen Gentamicin may be available in the countries listed below.
Gentamicin sulfate (a derivative of Gentamicin) is reported as an ingredient of Aspen Gentamicin in the following countries:
International Drug Name Search
Harosmin may be available in the countries listed below.
Fosfomycin is reported as an ingredient of Harosmin in the following countries:
International Drug Name Search
Lupram may be available in the countries listed below.
Citalopram hydrobromide (a derivative of Citalopram) is reported as an ingredient of Lupram in the following countries:
International Drug Name Search
Cefotaxim Copyfarm may be available in the countries listed below.
Cefotaxime sodium salt (a derivative of Cefotaxime) is reported as an ingredient of Cefotaxim Copyfarm in the following countries:
International Drug Name Search
Loratadine is reported as an ingredient of Children's Claritin in the following countries:
International Drug Name Search
GenRX Methylphenidate may be available in the countries listed below.
Methylphenidate hydrochloride (a derivative of Methylphenidate) is reported as an ingredient of GenRX Methylphenidate in the following countries:
International Drug Name Search
Kaman may be available in the countries listed below.
Paromomycin sulfate (a derivative of Paromomycin) is reported as an ingredient of Kaman in the following countries:
International Drug Name Search
Generic Name: Dacarbazine
Class: Antineoplastic Agents
VA Class: AN300
CAS Number: 4342-03-4
Use under supervision of a qualified clinician experienced in therapy with antineoplastic agents.100 Carefully weigh risks/benefits of therapy in each patient.100
Myelosuppression occurs commonly.100 (See Hematologic Effects under Cautions.)
Hepatic necrosis reported.100 (See Hepatic Effects under Cautions.)
Known carcinogen and teratogen in animals.100 (See Carcinogenicity and also Fetal/Neonatal Morbidity and Mortality, under Cautions.)
Antimetabolite antineoplastic agent; a purine analog.100
A systemic treatment of choice for the palliative treatment of metastatic melanoma.100 101 105 106 107 108 111 135 138 Has been used alone and in combination regimens†.105 106 107 108 111 135 Optimal regimen remains to be established.105 107 138
Treatment of advanced Hodgkin’s disease in combination with other antineoplastic agents.100 101 102 103 104 Often used with doxorubicin, bleomycin, and vinblastine (ABVD regimen).101 102 103 104
Consult specialized references for procedures for proper handling and disposal of antineoplastic drugs.100
For solution and drug compatibility information, see Compatibility under Stability.
Administer only by IV injection or infusion.100 b Extremely irritating to tissues; avoid extravasation.100 (See Local Effects under Cautions.)
Reconstitute vial containing 100 or 200 mg of dacarbazine powder with 9.9 or 19.7 mL, respectively, of sterile water for injection to provide a solution containing 10 mg/mL.100 c d
Reconstituted solution may be further diluted with 5% dextrose or 0.9% sodium chloride injection and infused IV.100 c d
IV injection: Administer over 1 minute.100 b
IV infusion: Infuse diluted solution over 15–30 minutes.100 b
Optimize results and minimize adverse effects by basing dose on clinical and hematologic response, patient tolerance, and other chemotherapy or irradiation being used.100 b
Consult published protocols for dosages in combination regimens and method and sequence of administration.b
2–4.5 mg/kg daily for 10 days; may repeat at 4-week intervals.100
Alternatively, 250 mg/m2 daily for 5 days; may repeat at 3-week intervals.100
150 mg/m2 daily for 5 days in combination with other antineoplastic agents; may repeat every 4 weeks.100
Alternatively, 375 mg/m2 on day 1, in combination with other antineoplastic agents; repeat every 15 days.100
Hypersensitivity to dacarbazine or any ingredient in the formulation.100
Administer only under supervision of a qualified clinician experienced in therapy with antineoplastic agents.100 (See Boxed Warning.)
Myelosuppression (principally severe leukopenia and thrombocytopenia) occurs commonly, generally 2–4 weeks after the last dose;100 b fatal leukopenia and thrombocytopenia reported.100 Anemia can occur.100 b
Carefully monitor hematologic status during therapy; evaluate leukocyte, erythrocyte, and platelet counts at frequent intervals.100
Hematopoietic toxicity (generally leukocyte count <3000/mm3 and platelet count <100,000/mm3) may require temporary withdrawal or discontinuance of the drug.100 b
Hepatotoxicity complicated by hepatic vein thrombosis and hepatocellular necrosis resulting in death has been reported.100 More common with combination regimens but also occurs with dacarbazine alone.100
May cause fetal harm; teratogenicity and embryolethality demonstrated in animals.100
Possible hypersensitivity reactions, including anaphylaxis.100
Photosensitivity reactions reported rarely.100
Carcinogenic effects reported in animals; importance in humans not known.100 b
Extravasation may result in tissue damage and severe pain.100
Undiluted solutions administered by IV injection may cause severe pain and phlebitis; some clinicians recommend dilution and infusion.b
Hot packs may relieve local pain, burning sensation, and irritation at the injection site.100
Category C.100
Not known whether dacarbazine is distributed into milk; discontinue nursing or the drug.100
Anorexia, nausea, vomiting, leukopenia, thrombocytopenia.100
Metabolized by hepatic microsomal enzymes.b
Enzyme inducers: Possible increased metabolism of dacarbazine.b
Drug | Interaction |
|---|---|
Phenobarbital | Possible increased dacarbazine metabolismb |
Phenytoin | Possible increased dacarbazine metabolismb |
Poorly absorbed from the GI tract.b
Volume of distribution exceeds total body water content, suggesting localization in a body tissue, probably the liver.100
Crosses blood-brain barrier to a limited extent; CSF concentrations approximately 14% of plasma concentrations.100
Not known whether dacarbazine crosses the placenta or is distributed into milk.100
Slightly bound.100
Extensively metabolized; hepatic microsomal enzymes are involved.100 b Some metabolites may contribute to the antineoplastic effect of the drug.b
Excreted in urine by tubular secretion; about 46% of an administered dose is excreted in urine within 6 hours (about 50% as unchanged drug and 50% as 5-amino-1H-imidazole-4-carboxamide [AIC]). (See Actions.)100 b
Biphasic; initial-phase half-life averages 19 minutes; terminal half-life averages 5 hours.100
2–8°C; protect from light.100
Use reconstituted solutions containing 10 mg/mL in sterile water for injection within 8 hours if stored at room temperature or 72 hours if stored at 4°C.100 d
Use solutions further diluted with ≤500 mL of 5% dextrose or 0.9% sodium chloride injection within 8 hours if stored at room temperature or 24 hours if stored at 4°C.100 b d
For information on systemic interactions resulting from concomitant use, see Interactions.
Variable |
|---|
Dextrose 5% in waterHID |
Sodium chloride 0.9%b |
Compatible |
|---|
Ondansetron HCl |
Variable |
Ondansetron HCl with doxorubicin HCl |
Incompatible |
Hydrocortisone sodium succinateb |
Compatible |
|---|
Amifostine |
Aztreonam |
Doxorubicin HCl liposome injection |
Etoposide phosphate |
Filgrastim |
Fludarabine phosphate |
Granisetron HCl |
Melphalan HCl |
Ondansetron HCl |
Paclitaxel |
Sargramostim |
Teniposide |
Thiotepa |
Vinorelbine tartrate |
Incompatible |
Allopurinol sodium |
Cefepime HCl |
Piperacillin sodium–tazobactam sodium |
Variable |
Heparin sodium |
Appears to exert cytotoxic effect by acting as an alkylating agent.100
Does not exhibit cell cycle-phase specificity.b
Synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC).100
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs as well as any concomitant illnesses.
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.100
Importance of informing patients of other important precautionary information. (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Parenteral | For injection, for IV use | 100 mg* | Dacarbazine for Injection | Abraxis |
200 mg* | Dacarbazine for Injection | Abraxis, Bedford, Mayne, Sicor | ||
DTIC-Dome (with anhydrous citric acid and mannitol) | Bayer |
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions August 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
† Use is not currently included in the labeling approved by the US Food and Drug Administration.
Only references cited for selected revisions after 1984 are available electronically.
100. Bayer Corporation. DTIC-Dome (dacarbazine) prescribing information. West Haven, CT; 1998 Sep.
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c. Bayer Corporation. DTIC-Dome (dacarbazine) prescribing information. West Haven, CT; 2003 May.
d. American Pharmaceutical Partners. Dacarbazine (for injection) prescribing information. Schaumburg, Illinois; 2002 April.
